Macutene Protect bottle
AREDS2®-based formula

Macutene® Protect

★★★★★ Verified Amazon reviews

Developed by retina specialists, Macutene® Protect is an AREDS2-based formula that contains or exceeds all the ingredients used in the AREDS2 clinical trial and has more than twice the amount of lutein & zeaxanthin to provide optimal macular support.

Help preserve sharp, detailed vision*
Help strengthen night vision*
Help reduce eye strain*
Contains additional ingredients clinically studied to support optimal macular health*
Subscribe & Save Save 10%1 bottle · delivered monthly · cancel anytime $35.99$39.99
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One-time purchase30-day supply · 60 capsules $39.99
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What it does

Daily nutrition for the macula & retina

Macutene® supplies the nutrients your eyes concentrate but diet often can't provide enough of — at the levels used in landmark research.

Macular carotenoids

Lutein and zeaxanthin are the pigments the macula naturally concentrates to filter high-energy blue light.

AREDS2®-based nutrition

Vitamin C, zinc and antioxidants at the researched levels, enriched with bilberry and quercetin.

For the long run

Two capsules a day to nourish the macula and retina consistently over time.

The formula

Carefully formulated from natural ingredients

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25 + 5 mg

Lutein & Zeaxanthin

Carotenoids that shield the macula from high-energy light and help protect against inflammation.

Found in: kale, spinach, broccoli
500 mg

Vitamin C

Forms collagen for ocular structure and adds antioxidant support.

Found in: citrus, bell peppers
25 mg

Zinc

The retina holds high concentrations of zinc; sufficient levels support macular health and dark adaptation.

Found in: shellfish, seeds, legumes
30 mg

Bilberry

Anthocyanin antioxidants that support the retina and help with night vision.

Found in: bilberry, blueberries
1 mg

Copper

Supports flexible connective tissue for eye structure and balances zinc intake.

Found in: nuts, whole grains
14 mg

Quercetin

A potent plant antioxidant that helps protect the retina from free-radical damage.

Found in: onions, apples, capers
The science

Built on the AREDS2® clinical trial

The Age-Related Eye Disease Studies (AREDS® and AREDS2®) were led by the National Eye Institute, part of the U.S. National Institutes of Health. They established that daily high doses of specific antioxidants and minerals can help support macular health.

Macutene® Protect is an AREDS2®-based formulation — built to those researched levels and enriched with additional lutein, zeaxanthin, bilberry, green tea and quercetin.

2
Capsules daily
30
Day supply
Every batch
Third-party tested
Physician Formulated
Lab-Tested
cGMP
Non-GMO
Gluten-Free
Vegan
Supplement Facts
Serving Size 2 Capsules
Servings Per Container 30
Amount Per Serving% DV
Vitamin C (ascorbic acid)500 mg556%
Vitamin E (d-alpha tocopherol succinate)268 mg1,787%
Zinc (as zinc citrate)25 mg227%
Copper (as copper citrate)1 mg111%
Green Tea (Camellia sinensis) Leaf Ext.30 mg
Bilberry (Vaccinium myrtillus) Fruit Ext.30 mg
Lutein (from marigold extract)25 mg
Zeaxanthin (from marigold extract)5 mg
Quercetin14 mg
† Daily Value (DV) not established.
Other ingredients: microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate, silicon dioxide, delayed-release vegetable capsule.
Non-GMOCertified VeganGluten-Free
What to expect · Daily use

Benefits that build over time.

Lutein and zeaxanthin deliver daily support and long-term nutritional coverage with consistent use.*

Week 1Early support for eye cells through nutritional intake.
Week 4Essential nutrient levels build to provide ongoing cellular support.
Week 8+Nutrient levels are maintained to help support macular function.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Why it's different

Made to a higher standard

Targets: Macula & retina — a daily formula built on clinical research, dosed transparently, and tested for purity.

Physician-formulated
Created by practicing ophthalmologists.
AREDS2®-based doses
Built to the levels used in the landmark trial.
Transparent, full-dose label
Every ingredient and milligram, printed.
Third-party tested
Independently verified for purity & potency.
Vegan, gluten-free & non-GMO
Clean, nature-based capsules.
Made in cGMP facilities
Produced in U.S. cGMP-certified facilities.
Who it's for

Extra care for aging eyes.

For anyone who wants to support their vision as they age — whether you're maintaining sharp, clear sight or simply nourishing your eyes with the nutrients diet alone rarely provides.

Reviews

Loved by our customers

★★★★★ Verified Amazon reviews
★★★★★

"My 85-year-old mother asked me to order these — she'd heard so many good things. She asked for two more bottles. Mom knows best!"

Sue · CT ✓ Verified buyer
★★★★★

"Awesome product."

Dottie S. ✓ Verified buyer
★★★★★

"Really pleased with my purchase — excellent for the care and health of the eyes. Thank you!"

Rebeca S. ✓ Verified buyer
★★★★★

"I've been taking this product for over a year and have found it very beneficial for my eyes. I will definitely continue buying it."

Mac ✓ Verified buyer
★★★★★

"Great supplement."

Amazon Customer ✓ Verified buyer
The difference

Not all eye supplements are equal

Macutene® ProtectTypical AREDS2 pill
Clinically-studied dosesOften reduced
Added lutein & zeaxanthin25mg / 5mg10mg / 2mg
Bilberry, green tea & quercetin
Certified vegan & non-GMOVaries
Third-party tested for purityRarely
Transparent, full-dose labelProprietary blends
Endorsed by ophthalmologists

"Most patients aren't getting enough nutrition to support their eyes through diet alone, so I recommend Pristene® supplements to provide the nutrition they need for healthy eyes."

Peter Kaiser, MD · Cole Eye Institute, Cleveland Clinic · Pristene Medical Advisory Board & Investor
FAQ

We're serious about facts. Ask away.

What is Macutene® Protect? +
A nature-based dietary supplement designed to support the macula and retina. It contains all the ingredients used in the AREDS2 clinical trial, plus additional lutein, zeaxanthin, bilberry, green tea and quercetin at optimal levels. Certified vegan, gluten-free and non-GMO, and independently lab-tested for quality, purity and potency.
How should I take it? +
Two capsules per day — either both at once, or one capsule twice daily.
How long until I see benefits? +
Macutene is intended to support your eyes; it does not treat or cure any eye disease or condition. It helps supplement your diet with the carotenoids and nutrients your eyes need for optimal health, so consistent daily use over time is best.
Can I take it with other supplements or medications? +
Macutene is generally well tolerated. As with any supplement, talk with your physician before starting — especially if you're pregnant, nursing, or taking medications.
What's your return policy? +
We offer a 60-day, no-questions-asked return policy. Just email support@pristene.com and we'll take care of you.

Give your eyes what they need

Start your subscription today — free shipping, 60-day guarantee, cancel anytime.

Add to cart — $35.99/mo

Held to a higher standard

Physician-FormulatedAREDS2®-BasedcGMP FacilitiesThird-Party Tested1,250+ Amazon Ratings