Our science

Formulated by physicians. Grounded in research.

Every Pristene formula starts with clinical evidence — not trends — and is dosed to the levels used in the research.

AREDS2®-based · Physician-formulated · Third-party tested · cGMP
AREDS2®
Based formulation
2.5×
More lutein than most brands
8+
Clinically-studied actives
100%
Transparent label
Macular science · AREDS2®
Clinical foundation

Built on landmark trials

The Age-Related Eye Disease Studies (AREDS and AREDS2) were multi-year clinical trials led by the U.S. National Eye Institute. AREDS2 refined the original formula — adding lutein and zeaxanthin — and helped define the antioxidants and minerals that support macular health.

Most supplements fall short of those researched doses. Macutene® Protect is built to them — then enriched with bilberry, green tea and quercetin, transparent to the last milligram.

Explore the ingredients →
Full transparency

Dosed to the research, not the label

The exact actives and amounts across our two formulas — Latin names, milligrams, nothing hidden.

Lutein & Zeaxanthin
Tagetes erecta
25 + 5 mg Macutene®
Vitamin C
Ascorbic acid
500 mg Macutene®
Zinc
Zinc citrate
25 mg Macutene®
Niacinamide (B3)
Nicotinamide
250 mg Neuroptene®
Bilberry
Vaccinium myrtillus
160 mg Neuroptene®
Saffron
Crocus sativus
30 mg Neuroptene®
How we formulate

Three principles, every product

01
Evidence first

Clinically-studied actives

We start with nutrients and botanicals backed by peer-reviewed research — not the latest trend.

02
Optimal levels

Doses that matter

We formulate to the levels used in research, not the minimum that fits a claim on the label.

03
Proven purity

Tested & certified

Every batch is third-party tested for purity and potency, produced in cGMP-certified facilities.

Quality, verified

Held to a higher standard

Non-GMO
Vegan
Gluten-Free
cGMP
Lab-Tested
Endorsed by ophthalmologists

"Most patients aren't getting enough nutrition to support their eyes through diet alone, so I recommend Pristene® supplements."

Peter Kaiser, MD · Cole Eye Institute, Cleveland Clinic · Pristene Medical Advisory Board & Investor

Science you can take daily

Explore the formulas built on it.

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